Association of elevated alpha 1-antichymotrypsin with cognitive impairment in a prospective study of the very old |
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Authors: | SM Gabriel DB Marin PS Aisen M Lantz LD Altstiel KL Davis RC Mohs |
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Affiliation: | Department of Psychiatry, Mount Sinai School of Medicine, Bronx, N.Y., USA. |
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Abstract: | OBJECTIVE: The authors investigated the relationships between concentrations of two acute-phase proteins, alpha 1-antichymotrypsin (ACT) and alpha 2-macroglobulin (MAC), and cognitive impairment in the very old. METHOD: Concentrations of ACT and MAC were determined in a prospective study using sera from medically stable elderly nursing home residents. Cognitive impairment was assessed with the Mini-Mental State. RESULTS: Concentrations of ACT were associated with greater cognitive impairment, as reflected by lower Mini-Mental State scores. This relationship did not exist for MAC. CONCLUSIONS: These data extend previous reports that patients with Alzheimer's disease have greater concentrations of ACT in their blood by demonstrating in a diagnostically diverse nursing home population a relationship between serum ACT and mental status. Elevated serum ACT in patients with compromised mental status may reflect a cerebral acute-phase response. |
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