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Synthesis of hydroxyapatite fibers using electrospinning: A study of phase evolution based on polymer matrix
Affiliation:1. Empa – Swiss Federal Laboratories for Materials Science and Technology, Laboratory for High Performance Ceramics, Überlandstrasse 129, CH-8600 Dübendorf, Switzerland;2. Institute of Ceramic, Glass and Construction Materials, Agricolastraße 17, 09599 Freiberg, Germany;1. Department of Materials Engineering, School of Engineering, Tarbiat Modares University, Tehran, 14115-143, Iran;2. Empa, Swiss Federal Laboratories for Materials Science & Technology, Laboratory for High Performance Ceramics, 8600, Dübendorf, Switzerland;3. Empa, Swiss Federal Laboratories for Materials Science & Technology, Transport at Nanoscale Interfaces Laboratory, 8600, Dübendorf, Switzerland;4. Empa, Swiss Federal Laboratories for Materials Science & Technology, Laboratory of Materials for Energy Conversion, 8600, Dübendorf, Switzerland;1. School of Engineering, Tarbiat Modares University, Tehran, Iran;2. Laboratory of High Performance Ceramics, Swiss Federal Laboratories for Materials Science & Technology (Empa), Duebendorf 8600, Switzerland;1. Empa, Swiss Federal Laboratories for Materials Science & Technology, 8600, Dübendorf, Switzerland;2. Electroceramic Department, Instituto de Cerámica y Vidrio, CSIC, Kelsen 5, 28049 Madrid, Spain;1. Physical Materials Science and Composite Materials Centre, National Research Tomsk Polytechnic University, 30 Lenin Avenue, Tomsk 634050, Russian Federation;2. Institute for Photon Science and Synchrotron Radiation of the Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen 76344, Germany;3. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142292, Russia;4. Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Straße 4, Marburg 35032, Germany;5. Jozef Stefan Institute, Ljubljana, Slovenia;6. Institute of Solid State Chemistry and Mechanochemistry of the Siberian Branch of the RAS, Kutateladze, 18, Novosibirsk 630128, Russian Federation;1. State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute at Sichuan University, Chengdu 610065, China;2. State Key Laboratory of Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China;1. School of Integrative Engineering, Chung-Ang University, Seoul 06974, South Korea;2. Pharmaceutical Sciences Division, University of Wisconsin, Madison, WI 53705, USA;3. Department of Biomedical Science, Dongguk University, Gyeonggi 10326, South Korea
Abstract:Hydroxyapatite (HA) is considered as the most promising biomaterial candidate to replace and regenerate hard tissues. A small amount of β-tricalcium phosphate (β-TCP) phase is advantageous for rapid bonding of the artificial bones to natural ones due to its high solubility compared to hydroxyapatite. Synthesizing HA nanofibers from electrospinning of sol-gel is considered as a widely researched topic. Motivation of the current work was to investigate the influence of polymeric binder in the final phase evolution after heat treatment of electrospun nanofibers. Calcium phosphate nanofibers were fabricated by electrospinning sols using gelatine and polyvinylpyrrolidone as carrier polymers and subjected to heat treatment. It was realized that carrier polymers facilitate preferential calcium phosphate phase formation by forming hydroxyapatite as major phase while PVP was used and β-TCP with HA as secondary phase while gelatine was employed. XRD and thermal analyses were performed to ascertain the reason behind this interesting behaviour.
Keywords:Hydroxyapatite  Electrospinning  β-tricalcium phosphate  Ceramic biomaterial
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