LC-MS/MS法测定纸质包装材料中15种光引发剂向改性聚苯醚模拟物的迁移量

为了考察光引发剂的迁移特性，评估安全风险，建立了一种基于液相色谱 串联质谱（LC-MS/MS）分析纸质包装材料中15种光引发剂向改性聚苯醚（MPPO）模拟物迁移量的方法。纸质包装材料中迁移出的被分析物被MPPO吸附后用乙腈萃取，萃取液经有机滤膜过滤后，采用乙腈和0.1%甲酸水溶液作为流动相进行梯度洗脱，Luna PFP(2)色谱柱（150 mm×4.6 mm×3 μm）分离，串联质谱法分析，外标法定量。通过对色谱条件优化，15种光引发剂在12 min内可实现有效分离，且目标分析物在0.01~0.2 mg/kg范围内线性关系良好，线性相关系数R²>0.993。3个加标水平（0.01、0.05和0.2 mg/kg）的回收率在70.2％～122.5%之间，相对标准偏差（RSD）小于7.5％，检出限（LOD）为0.001～0.021 mg/kg。实际样品的分析结果表明，该方法的检出限低、测定结果准确，可用于纸质包装材料中15种光引发剂向改性聚苯醚模拟物迁移量的检测。

Determination of Migration of the 15 Photoinitiators from Paper-Made Packing Using Modified Polyphenylene Oxide as a Simulant by LC-MS/MS

In order to investigate the migration behavior of the PIs for the security risk assessment， the migrations of 15 photoinitiators (PIs) from paper-made packing using modified polyphenylene oxide (MPPO) as a simulant were determined using liquid chromatography-tandem mass spectrometry (LC-MS/MS) MPPO, which was adsorbed the PIs migrated from paper-made packing, was extracted using acetonitrile, followed by clean-up of extract using organic phase filter. The PIs were separated in 12 min on the column of Luna PFP(2) by gradient elution with acetonitrile and water with 0.1% formic acid as mobile phase All the PIs have good linear relationship (R²>0.993) with in 0.01-0.2 mg/kg. The recoveries of 15 PIs are in the range of 70.2％-122.5％ at the spike levels of 0.01, 0.05 and 0.2 mg/kg with the relative standard deviation less than 7.5%. The limits of detection range from 0.001 to 0.021 mg/kg. The analysis of real sample shows that the method with high sensitivity and high accuracy can be applied for the determination of migration of PIs from paper-made packing.