Inhibition of hepatic cholesterol biosynthesis by chloroquine |
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| Authors: | Anton C Beynen Ate J Van Der Molen Math J H Geelen |
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| Affiliation: | (1) Laboratory of Veterinary Biochemistry, State University of Utrecht, Biltstraat 172, 3572 BP Utrecht, The Netherlands |
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| Abstract: | Chloroquine is shown to be a potent inhibitor of cholesterol biosynthesis by isolated rat hepatocytes. Half-maximal inhibition
of cholesterogenesis occurs at ca. 10μM chloroquine. Chloroquine does not affect fatty acid synthesis by isolated hepatocytes.
This suggests that chloroquine acts on the cholesterol biosynthetic pathway beyond the cytosolic acetyl-CoA branchpoint of
cholesterol and fatty acid synthesis. |
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