CSF levels of carnitine in children with meningitis, neurologic disorders, acute gastroenteritis, and seizure |
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Authors: | M Shinawi N Gruener A Lerner |
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Affiliation: | Department of Pediatrics, Carmel Medical Center, Haifa, Israel. |
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Abstract: | Carnitine concentrations in CSF, serum, and urine in normal febrile children and children with meningitis, neurologic disorders, and dehydration were studied. Carnitine levels in CSF were 1/10 compared with serum in normal febrile children. These levels increased two- to three-fold in the pathologic conditions studied. Since damage to the blood-brain barrier occurs in these conditions, higher blood-brain barrier permeability might explain CNS carnitine accumulation. |
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