915 nm Light‐Triggered Photodynamic Therapy and MR/CT Dual‐Modal Imaging of Tumor Based on the Nonstoichiometric Na0.52YbF3.52:Er Upconversion Nanoprobes |
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| Authors: | Yanan Huang Qingbo Xiao Huishan Hu Kunchi Zhang Yamin Feng Fujin Li Jian Wang Xianguang Ding Jiang Jiang Yanfang Li Liyi Shi Hongzhen Lin |
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| Affiliation: | 1. i‐Lab, Suzhou Institute of Nano‐tech and Nano‐bionics (SINANO), Chinese Academy of Sciences, Suzhou, China;2. College of Sciences, Shanghai University, Shanghai, China;3. Suzhou Key Laboratory of Nanobiomedicine, Division of Nanobiomedicine, Suzhou Institute of Nano‐tech and Nano‐bionics (SINANO), Chinese Academy of Sciences, Suzhou, China |
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| Abstract: | Lanthanide (Ln3+)‐doped upconversion nanoparticles (UCNPs) as a new generation of multimodal bioprobes have attracted great interest for theranostic purpose. Herein, red emitting nonstoichiometric Na0.52YbF3.52:Er UCNPs of high luminescence intensity and color purity are synthesized via a facile solvothermal method. The red UC emission from the present nanophosphors is three times more intense than the well‐known green emission from the ≈30 nm sized hexagonal‐phase NaYF4:Yb,Er UCNPs. By utilizing Na0.52YbF3.52:Er@SrF2 UCNPs as multifunctional nanoplatforms, highly efficient in vitro and in vivo 915 nm light‐triggered photodynamic therapies are realized for the first time, with dramatically diminished overheating yet similar therapeutic effects in comparison to those triggered by 980 nm light. Moreover, by virtue of the high transverse relaxivity (r 2) and the strong X‐ray attenuation ability of Yb3+ ions, these UCNPs also demonstrate good performances as contrast agents for high contrast magnetic resonance and X‐ray computed tomography dual‐modal imaging. Our research shows the great potential of the red emitting Na0.52YbF3.52:Er UCNPs for multimodal imaging‐guided photodynamic therapy of tumors. |
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| Keywords: | 915 nm bioimaging photodynamic therapy upconversion nanoparticles |
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