Intracellular Dual Fluorescent Lightup Bioprobes for Image‐Guided Photodynamic Cancer Therapy |
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| Authors: | Haijie Han Qiao Jin Haibo Wang Wenzhuo Teng Jina Wu Hongxin Tong Tingting Chen Jian Ji |
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| Affiliation: | 1. MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China;2. Textile Institute, College of Light Industry, Textile and Food Engineering, Sichuan University, Chengdu, China |
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| Abstract: | An intracellular dual fluorescent light‐up bioprobe with aggregation‐induced emission features and endogenously producing photosensitizer protoporphyrin IX (PpIX) abilities is designed and synthesized. The bioprobe is nonemissive in physiological environment. However, the bioprobe can selectively light up cancer cells with blue fluorescence of tetraphenylene (TPE) and red fluorescence of PpIX, owing to the release of TPE and methyl aminolevulinate after targeted internalization by cancer cells. Moreover, upon endogenous generation and accumulation of PpIX in cancer cells, efficient photodynamic ablation of cancer cells after light irradiation is demonstrated with easy regulation for optimal therapeutic efficacy. The design of such dual fluorescent light‐up bioprobes might provide a new opportunity for targeted and image‐guided photodynamic cancer therapy. |
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| Keywords: | 5‐aminolevulinic acid AIE endogenous photosensitizers fluorescent lightup photodynamic therapy |
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