Facile Synthesis of Yolk–Shell‐Structured Triple‐Hybridized Periodic Mesoporous Organosilica Nanoparticles for Biomedicine |
| |
Authors: | Zhaogang Teng Junjie Zhang Wei Li Yuanyi Zheng Xiaodan Su Yuxia Tang Meng Dang Ying Tian Lihui Yuwen Lixing Weng Guangming Lu Lianhui Wang |
| |
Affiliation: | 1. Key Laboratory for Organic Electronics and Information Displays & Istitute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Centre for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing, P. R. China;2. Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, P. R. China;3. State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, P. R. China;4. Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Laboratory of Advanced Materials, Fudan University, Shanghai, P. R. China;5. Second Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China |
| |
Abstract: | The synthesis of mesoporous nanoparticles with controllable structure and organic groups is important for their applications. In this work, yolk–shell‐structured periodic mesoporous organosilica (PMO) nanoparticles simultaneously incorporated with ethane‐, thioether‐, and benzene‐bridged moieties are successfully synthesized. The preparation of the triple‐hybridized PMOs is via a cetyltrimethylammonium bromide‐directed sol–gel process using mixed bridged silsesquioxanes as precursors and a following hydrothermal treatment. The yolk–shell‐structured triple‐hybridized PMO nanoparticles have large surface area (320 m2 g–1), ordered mesochannels (2.5 nm), large pore volume (0.59 cm3 g–1), uniform and controllable diameter (88–380 nm), core size (22–110 nm), and shell thickness (13–45 nm). In vitro cytotoxicity, hemolysis assay, and histological studies demonstrate that the yolk–shell‐structured triple‐hybridized PMO nanoparticles have excellent biocompatibility. Moreover, the organic groups in the triple‐hybridized PMOs endow them with an ability for covalent connection of near‐infrared fluorescence dyes, a high hydrophobic drug loading capacity, and a glutathione‐responsive drug release property, which make them promising candidates for applications in bioimaging and drug delivery. |
| |
Keywords: | biomedical applications mesoporous materials periodic mesoporous organosilica triple‐hybridization yolk– shell structures |
|
|