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| 水溶性壳聚糖衍生物在壳聚糖膜表面的化学固定及抗凝血性能研究 | |
| 引用本文： | 胡玉锋,毛春,李利,周宁琳,魏少华,沈健.水溶性壳聚糖衍生物在壳聚糖膜表面的化学固定及抗凝血性能研究[J].化工新型材料,2005,33(3):19-21. |
| 作者姓名： | 胡玉锋 毛春 李利 周宁琳 魏少华 沈健 |
| 作者单位： | 1. 南京师范大学化学与环境科学学院,南京,210097;江苏省生物医药功能材料工程研究中心,南京,210097 2. 江苏省生物医药功能材料工程研究中心,南京,210097 3. 南京师范大学化学与环境科学学院,南京,210097;江苏省生物医药功能材料工程研究中心,南京,210097;南京大学表面和界面化学工程技术研究中心,南京,210093 |
| 基金项目： | 江苏省教育厅基金项目(JH03 013,JHjd03 008,04KJB430072)。 |
| 摘 要： | 合成了N-双取代亚甲基磷酸壳聚糖,并且对其进行了表征。通过戊二醛交联的方法将N- 双取代亚甲基磷酸壳聚糖固定在壳聚糖薄膜表面。对接枝前后膜表面的结构性能和血液相容性进行表征,结果显示N -双取代亚甲基磷酸壳聚糖被有效地固定在壳聚糖膜表面,并且能够有效地抑制血小板在壳聚糖膜表面的粘附。 |
| 关 键 词： | 壳聚糖 血液相容性 表面改性 血小板粘附 |
| 修稿时间： | 2005年1月7日 |
The study of introduction of water soluble chitosan derivates to chitosan film for chemical grafting and anticoagulation |
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| Hu Yufeng,Mao Chun,Li Li,ZHOU Ninglin,Wei Shaohua,Shen Jian.The study of introduction of water soluble chitosan derivates to chitosan film for chemical grafting and anticoagulation[J].New Chemical Materials,2005,33(3):19-21. | |
| Authors: | Hu Yufeng Mao Chun Li Li ZHOU Ninglin Wei Shaohua Shen Jian |
| Affiliation: | Hu Yufeng 1,2 Mao Chun2 Li Li 1,2 Zhou Ningli n 1,2 Wei Shaohua 1,2 Shen Jian 1,2,3 |
| Abstract: | Based on tests in vitro for an improvement of the blood compatibility of chitosan films by grafting N-methyle ne phosphonic chitosan (MPCS),we prepared a novel biocompatible film. The immobi lization was accomplished by chemical grafting using glutaraldehyde.The grafted sample films were verified by ATR-FTIR,ESCA and the water contact angle measure ments.The blood compatibility of the MPCS grafted chitosan films was evaluated b y platelet rich plasma(PRP)contacting experiments using blank chitosan film as t he control.It demonstrated that blood compatibility of the MPCS grafted surfaces is better than that of the blank chitosan.These results suggested that the wate r soluble chitosan derivates developed here has the potential of serving as a ne w biomaterial in medical use. |
| Keywords: | chitosan blood compatibility surface modifica tion platelet adhesion |
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