| 超声波辐射下草酸催化合成3,4-二氢嘧啶-2(1H)-酮 |
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| 引用本文： | 王勤,裴文. 超声波辐射下草酸催化合成3,4-二氢嘧啶-2(1H)-酮[J]. 化学试剂, 2010, 32(4) |
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| 作者姓名： | 王勤 裴文 |
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| 作者单位： | 1. 扬州工业职业技术学院,化学工程系,江苏,扬州,225127;浙江工业大学,化学工程与材料学院,浙江,杭州,310014
2. 浙江工业大学,化学工程与材料学院,浙江,杭州,310014 |
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| 摘 要： | 采用草酸为催化剂,由醛、1,3-二羰基化合物和脲(硫脲)在无溶剂超声波辐射下,简单有效地合成了标题化合物.和传统方法相比,该方法具有反应时间短(<1.5 h)、收率高(78%～92%)、分离简单等优点.
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| 关 键 词： | 超声波辐射 草酸 3,4-二氢嘧啶-2(1H)-酮 无溶剂 |
Oxalic acid catalyzed synthesis of 3,4-dihydropyrimidin-2(1H)-ones under ultrasonic irradiation |
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| WANG Qin,PEI Wen. Oxalic acid catalyzed synthesis of 3,4-dihydropyrimidin-2(1H)-ones under ultrasonic irradiation[J]. Chemical Reagents, 2010, 32(4) |
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| Authors: | WANG Qin PEI Wen |
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| Abstract: | A simple and efficient method for synthesis of 3,4-dihydropyrimidin-2(1H)-ones or thiones from aldehyde,1,3-dicarbonyl compound,and urea (thiourea) was described,using oxalic acid as the catalyst under ultrasonic irradiation and solvent-free conditions.The product yields could reach 78%～92%.Compared with the classical method,this method has featured short reaction time (<1.5 h),high yields (78%～92% based on aldehydes) and easiness for separation. |
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| Keywords: | ultrasound irradiation oxalic acid 3,4-dihydropyrimidin-2(1H)-one solvent-free |
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