Effects of naloxone on upper airway collapsibility in normal sleeping subjects |
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Authors: | JC Meurice I Marc F Sériès |
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Affiliation: | Unité de Recherche, Centre de Pneumologie, H?pital Laval, Université Laval, Sainte-Foy, Québec, Canada. |
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Abstract: | BACKGROUND: To evaluate the possible influence of endorphin release on upper airway collapsibility the effects of naloxone, an opiate receptor antagonist, were measured. METHODS: The effects of naloxone on upper airway collapsibility were studied in five normal sleeping men in a pilot study. During a sleep fragmentation night the subjects received either naloxone or a volume matched saline placebo in a double blind crossover design. Critical pressure (Pcrit) was measured during a morning nap following sleep fragmentation. RESULTS: The plasma levels of endorphins increased during sleep fragmentation nights. Pcrit was significantly greater after placebo than after naloxone infusion. CONCLUSIONS: Naloxone may reduce upper airway collapsibility in normal sleeping subjects following sleep fragmentation. |
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