重要的原料药—辅酶Q10

辅酶Q10的合成方法有4种生物提取法、微生物发酵法、半化学合成法、化学合成法,其中微生物发酵法是近几年国内外开发的热点,被认为是较有前途的合成工艺.日本是最主要的辅酶Q10生产国,据统计,全球90%的辅酶Q10来自日本,日清制粉和协和发酵工业公司是产量最高的两家公司.我国目前采用生物提取法生产辅酶Q10总生产能力约为600kg/a,而2000年我国几个主要海关辅酶Q10的进口量就达14689kg,出口量为1278kg,市场缺口较大.我国茄呢醇生产能力接近100t/a(折百),应充分利用原料资源优势,攻克半合成法生产辅酶Q10的难关.

An Important Bulk Pharmaceutical :Coenzyme Q10

There are four synthesis methods of coenzyme Q10 : bio-extraction, microbiological fermentation, semi-chemical synthesis and chemical synthesis. Among these, microbiological fermentation method is the hot spot of development at home and abroad and considered to be a synthesis process with broad prospects. Japan is the most important producer of coenzyme Q10. According to statistics, 90% coenzyme Q10 in the world is from Japan, Nissin Powder Mills Ltd. and Kyowa Hakko Kogyo Co. , Ltd. have the biggest output. In China, bio-extraction method is adopted for manufacturing coenzyme Q10, with total capacity of 600kg/a, however, the imports were 14689kg in 2000, exports were 1278kg, there was a bigger market gap. Because China' s solanesol capacity is bigger, the country should make the best use of raw material resource advantage, make breakthroughs in semi-synthesis method for manufacturing coenzyme Q10.