Micronization of fenofibrate by rapid expansion of supercritical solution |
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| Affiliation: | 1. Materials and Surface Science Institute, Department of Chemical and Environmental Science, University of Limerick, Limerick, Ireland;2. Department of Chemical Engineering and Technology, KTH Royal Institute of Technology, SE-10044 Stockholm, Sweden;1. Department of Chemical Engineering and Environmental Technology, University of Valladolid, c/ Doctor Mergelina s/n, 47011 Valladolid, Spain;2. TERMOCAL Research Group, University of Valladolid, c/ Paseo del Cauce 59, 47011 Valladolid, Spain;1. Department of Chemical Engineering, Faculty of Engineering, University of Kashan, Postal Code: 87317-53153, Kashan, Iran;2. Laboratory of Supercriritcal Fluids and Nanotechnology, University of Kashan, Postal Code: 87317-53153, Kashan, Iran;1. Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, Republic of Korea;2. Department of Chemical Engineering, ILRI, Kyunghee University, Kyungki-do, Republic of Korea |
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| Abstract: | Micronization of fenofibrate was investigated using rapid expansion of supercritical solution (RESS) process. Effects of pressure, temperature and nozzle on particle size were optimized using Taguchi's orthogonal array and analyzed using XRD, DSC, FT-IR, SEM, laser diffractometer and dissolution testing. Processed fenofibrate retained crystalline structure and has a similar chemical structure with unprocessed fenofibrate. The average particle size of fenofibrate was reduced from its original 68.779 ± 0.146 μm to 3.044 ± 0.056 μm under the optimum condition (T at 35 °C, P at 200 bar and nozzle diameter at 200 μm). The processed fenofibrate showed an enhanced dissolution rate by 8.13 times. |
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| Keywords: | Fenofibrate RESS Particle size |
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