Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects |
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Authors: | Shu-Jun Fan Bo-Yi Yang Xue-Yuan Zhi Miao He Da Wang Yan-Xun Wang Yi-Nuo Wang Jian Wei Quan-Mei Zheng Gui-Fan Sun |
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Affiliation: | 1.Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110013, China; E-Mails: (S.-J.F.); (B.-Y.Y.); (X.-Y.Z.); (M.H.); (D.W.); (Q.-M.Z.);2.Division of Molecular Preventive Medicine, Shanghai Institute of Targeted Therapy and Molecular Medicine, Shanghai 200433, China; E-Mails: (Y.-X.W.); (Y.-N.W.);3.Brain Disease Center, Tianjin Dagang Oil Field General Hospital, Tianjin 300280, China; E-Mail: (J.W.) |
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Abstract: | Several studies have examined the associations of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms with being overweight/obesity. However, the results are still controversial. We therefore conducted a case-control study (517 cases and 741 controls) in a Chinese Han population and then performed a meta-analysis by combining previous studies (5431 cases and 24,896 controls). In our case-control study, the MTHFR C677T polymorphism was not significantly associated with being overweight/obesity when examining homozygous codominant, heterozygous codominant, dominant, recessive and allelic genetic models. The following meta-analysis confirmed our case-control results. Heterogeneity was minimal in the overall analysis, and sensitivity analyses and publication bias tests indicated that the meta-analytic results were reliable. Similarly, both the case-control study and meta-analysis found no significant association between the MTRR A66G polymorphism and being overweight/obesity. However, sensitivity analyses showed that the associations between the MTRR A66G polymorphism and being overweight/obesity became significant in the dominant, heterozygous codominant and allelic models after excluding our case-control study. The results from our case-control study and meta-analysis suggest that both of the two polymorphisms are not associated with being overweight/obesity. Further large-scale population-based studies, especially for the MTRR A66G polymorphism, are still needed to confirm or refute our findings. |
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Keywords: | MTHFR MTRR overweight obesity polymorphism |
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