Improved bioabsorbability of synthetic hydroxyapatite through partial dissolution-precipitation of its surface |
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Authors: | Xianjun Ding Masahiko Takahata Toshiyuki Akazawa Norimasa Iwasaki Yuichiro Abe Miki Komatsu Masaru Murata Manabu Ito Kuniyoshi Abumi Akio Minami |
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Affiliation: | (1) Department of Orthopedic Surgery, Graduate School of Medicine, Hokkaido University, Kita-15 Nishi-7, Kita-ku, Sapporo 060-8638, Japan;(2) Hokkaido Research Organization, Industrial Research Institute, Industrial Technology Research Development, Local Independent Administrative Agency, Sapporo, Japan;(3) 2nd Department of Oral Surgery, Health Sciences University of Hokkaido, Sapporo, Japan; |
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Abstract: | Even though synthetic hydroxyapatite (HAp) has a chemical composition similar to the mineral phase of bone, it is minimally
absorbed and replaced by bone tissue. This could be because HAp is composed of compactly arranged apatite crystals with homogenously
large grains. In this study, the surface and non-stoichiometry of the synthetic HAp crystals was modified by partial dissolution
and precipitation (PDP) to improve bioabsorbability of HAp. In vitro cell culture demonstrated that more osteoclasts were
activated on PDP-HAp compared with HAp. In vivo implantation using a rabbit bone defect model revealed that PDP-HAp was gradually
degraded and was replaced by bone tissue. Consistent with the in vitro results, more osteoclasts were activated in PDP-HAp
than in HAp, indicating that the former was absorbed through the stimulation of osteoclastic activity. These results suggest
that the PDP technique may have clinical utility for modifying synthetic HAp for use as superior bone graft substitutes. |
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