Antimicrobial activity of native chitosan,degraded chitosan,and O-carboxymethylated chitosan |
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Authors: | Kim Kyung W Thomas R L Lee Chan Park Hyun J |
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Affiliation: | Department of Packaging Science, Clemson University, Clemson, South Carolina 29634-0370, USA. |
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Abstract: | The antimicrobial activity of native chitosan was compared to that of lipase-degraded chitosan. The effects of O-carboxymethylated (O-CM) substitution on native (molecular weight, 120; degree of deacetylation, 84.71%) and lipase-degraded chitosans were also investigated. The antimicrobial activity of native chitosan was more extensive than that of lipase-degraded chitosan; however, lipase-degraded chitosan was still highly effective and more water-soluble. O-CM chitosan derived from degraded chitosan was more effective than O-CM chitosan derived from native chitosan. O-CM substitution enhanced lipase-degraded chitosan's antimicrobial activity without reducing its solubility. |
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