甘薯糖蛋白降血糖与抗氧化作用研究

目的:研究甘薯糖蛋白(SPG)对四氧嘧啶诱导的糖尿病小鼠的降血糖作用及体内抗氧化活性。方法:经水溶提取、乙醇沉淀、凝胶过滤层析,从广薯98中提取甘薯糖蛋白,并研究SPG对四氧嘧啶诱导的糖尿病小鼠血糖浓度,肝、脑组织及血清中SOD、CAT活力和MDA含量的影响。结果:SPG对四氧嘧啶诱导的糖尿病小鼠具有明显的降血糖功能(p<0.01),SPG能明显增加四氧嘧啶诱导的糖尿病小鼠肝、脑组织及血清中SOD和CAT的活性(p<0.05或p<0.01),SPG能明显降低四氧嘧啶诱导的糖尿病小鼠肝、脑组织及血清中MDA的含量(p<0.01)。结论:SPG对四氧嘧啶诱导的糖尿病小鼠具有明显的降血糖作用和明显的体内抗氧化活性。

Study on Hypoglycemic Effect and Antioxidation of Sweet Potato Glycoprotein

Objective:To study hypoglycemic effect and antioxidation of sweet potato glycoprotein(SPG) on alloxan-iduced diabetic mice.Methods:SPG was obtained from the cultivar Guangdong 98 via water extraction,alcohol precipitation and gel filtration.The effects of SPG on blood glucose contents were discussed activities of SOD and CAT and the contents of MDA in liver,brain and serum of the can diabetic mice were discussed.Results:SPG lowers the blood glucose contents of diabetic mice(p<0.01),increases the activities of SOD and CAT(p<0.05 or p<0.01) and decreases the contents of MDA(p<0.01) in liver,brain and serum.Conclusion:SPG can significantly lower the blood glucose and has in vivo antioxidation function to alloxan diabetic mice.