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Porous methacrylate tissue engineering scaffolds: using carbon dioxide to control porosity and interconnectivity |
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| Authors: | John J. A. Barry Marta M. C. G. Silva Sarah H. Cartmell Robert E. Guldberg Colin A. Scotchford Steven M. Howdle |
| Affiliation: | (1) School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK;(2) Orthopaedic Bioengineering Laboratory, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 315 Ferst Drive, NW IBB Building, Room 2311, Atlanta, GA 30332-0405, USA;(3) School of Biomedical Sciences, University of Nottingham Medical School, Queen’s Medical Centre, Nottingham, NG7 2UH, UK;(4) Bioengineering Section, School of Mechanical, Materials, Manufacturing Engineering and Management, University of Nottingham, Nottingham, NG7 2RD, UK |
| Abstract: | Porous scaffold structures are used in tissue engineering to provide structural guidance for regenerating tissues. The use of carbon dioxide (CO2) to create such scaffolds has received some attention in the past but many researchers believe that although CO2 processing of polymers can lead to porous scaffolds there is limited interconnectivity between the pores. In this study, highly porous (greater than 85%) and well interconnected scaffolds were obtained in which the size, distribution and number of pores could be controlled. This control was achieved by altering the rate of venting from polymer discs saturated with CO2 under modest temperature and pressure. The polymer used is a blend of poly (ethyl methacrylate) and tetrahydrofurfuryl methacrylate (PEMA/THFMA). This polymer system has shown promise for potential applications in cartilage repair. |
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