细胞外超氧化物歧化酶基因转移及活性调控的研究进展

超氧化物(O2.-)与许多病理过程有关,通过细胞外超氧化物歧化酶(ecSOD)基因转移除去细胞外的超氧化物,对于治疗因氧化应激反应过强而引发的血管疾病具有广阔的前景。最近的研究已揭示了ecSOD的表达调控以及肝素取代等方面的相关机制,为探讨ecSOD如何与其他因素协同作用,从而调节血管功能的机理提供了新的思路。本文对ecSOD基因转移及活性调控的最新研究进展作一综述。

Advances in Gene Transfer and Activity Regulation of Extracellular Superoxide Dismutase

Superoxide (O2.-)has involvement in many pathological processes,and removal of extracellular O2.-by extracellu-lar superoxide dismutase(ecSOD)gene transfer serves as a promising treatment of vascular disorders associated with increased oxidant stress. Recent studies have clarified mechanisms concerning the regulation of ecSOD expression and tissue binding,which provides new insight into how ecSOD interacts with other factors to regulate vascular function. This review is surposed to summarize novel findings of ecSOD and to stimulate investigations into the role of ecSOD in the treatment of cardiovascular disease.