| 二代PAMAM树型高分子的荧光现象及其荧光标记应用 |
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| 引用本文： | 王东军,贾丹丹,沈喜海,甄珍,刘新厚. 二代PAMAM树型高分子的荧光现象及其荧光标记应用[J]. 功能材料, 2006, 37(12): 1864-1866 |
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| 作者姓名： | 王东军 贾丹丹 沈喜海 甄珍 刘新厚 |
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| 作者单位： | 河北科技师范学院,化学系,河北,秦皇岛,066600;中国科学院理化技术研究所,北京,100101 |
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| 基金项目： | 国家自然科学基金 , 河北省博士科研项目 |
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| 摘 要： | 首次发现不含荧光团的二代poly(amido amine) (PAMAM) 树型高分子的荧光现象,研究结果表明在无荧光基团的PAMAM树型高分子中,胺类官能团是产生荧光的关键.不同酸度条件下,生成荧光中心的速度不同,而且荧光的稳定性也不相同.同时发现当反复变换酸碱性时PAMAM树型高分子的荧光强度逐渐变弱.由于低代PAMAM树型高分子的良好生物相容性和低廉价格,其有可能成为新型生物荧光标记物.
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| 关 键 词： | 荧光 PAMAM树型高分子 无荧光基团 生物相容 荧光标记 |
| 文章编号： | 1001-9731(2006)12-1864-03 |
| 收稿时间： | 2006-04-18 |
| 修稿时间： | 2006-09-26 |
The fluorescence emitted from low generation PAMAM dendrimer and its application in fluorescence labeling |
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| WANG Dong-jun,JIA Dan-dan,SHEN Xi-hai,ZHEN Zhen,LIU Xin-hou. The fluorescence emitted from low generation PAMAM dendrimer and its application in fluorescence labeling[J]. Journal of Functional Materials, 2006, 37(12): 1864-1866 |
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| Authors: | WANG Dong-jun JIA Dan-dan SHEN Xi-hai ZHEN Zhen LIU Xin-hou |
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| Affiliation: | 1. Department of Chemistry, Hebei Normal University of Science and Technology, Qinghuangdao 066600,China; 2. Institute of Science and Technology,Chinese Academy of Sciences,Beijing 100101 ,China |
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| Abstract: | Based on the experiment results of fluorescence from low generation PAMAM dendrimer,it can be proposed that amine groups in PAMAM dendrimer play the critical role in emitting fluorescence,but not the crowding state of these amine groups. At different pH values, the speed of forming fluorescence centers and the fluorescence stability were observed to be different. The intensity of fluorescence would be obviously reduced after varying the pH value between 10 and 3 for several times. Because of its high biocompatibility and low price,low generation PAMAM dendrimer may find applications as a new kind of fluorescence indicator. |
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| Keywords: | fluorescence PAMAM dendrimer without fluorophore blocompatibility fluorescence labeling |
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