| 6-取代蝶啶酮衍生物的合成 |
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| 引用本文： | 杨州,王艰,许秀枝,张春玲,李柱来.6-取代蝶啶酮衍生物的合成[J].精细化工中间体,2012,42(3):31-34,43. |
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| 作者姓名： | 杨州 王艰 许秀枝 张春玲 李柱来 |
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| 作者单位： | 福建医科大学药学院,福建福州,350004 |
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| 基金项目： | 福建省教育厅基金，福建医科大学教授学术发展基金计划资助 |
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| 摘 要： | 以3-氨基吡嗪-2-羧酸甲酯为起始原料,采用3种改进后的新方法通过氨解、溴代、环合及取代反应合成6个新的蝶啶酮衍生物。反应时间可由传统方法的5～6 h缩短至2～3 h,目标物收率由52%～63%提高至89%～93%。其结构经1H NMR、MS、IR等确认。
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| 关 键 词： | 蝶啶 合成 表征 精细化工中间体 |
Study on the Synthesis, Characterization and Process Improvement of 6-Subsitituted Pteridinone Derivatives |
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| YANG Zhou
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WANG Jian
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XU Xiu-zhi
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ZHANG Chun-ling
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LI Zhu-lai.Study on the Synthesis, Characterization and Process Improvement of 6-Subsitituted Pteridinone Derivatives[J].Fine Chemical Intermediates,2012,42(3):31-34,43. |
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| Authors: | YANG Zhou WANG Jian XU Xiu-zhi ZHANG Chun-ling LI Zhu-lai |
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| Affiliation: | (College of Pharmacy,Fujian Medical University,Fuzhou 350004,China) |
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| Abstract: | Six novel pteridinone analogues were synthesized starting from 3-amino-pyrazine-2-carboxylic acid methyl ester by three improved methods.Comparing with the conventional method,the new routes can reduce the reaction time from 5~6 hours to 2~3 hours,and increase the yield of the target product from 52~63% to 89~93%.The compounds were characterized with 1H NMR,MS and IR spectra. |
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| Keywords: | pteridine synthesis characterization |
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