| 3-溴-5-叔丁基-2-羟基苯甲醛的合成研究 |
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| 引用本文： | 张星,惠建斌. 3-溴-5-叔丁基-2-羟基苯甲醛的合成研究[J]. 精细化工中间体, 2012, 42(3): 17-20 |
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| 作者姓名： | 张星 惠建斌 |
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| 作者单位： | 中国科学院过程工程研究所,北京100190;中国科学院唐山高新技术研究与转化中心,河北唐山063020 |
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| 基金项目： | 中科院知识创新重要方向性项目，唐山市科技局项目 |
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| 摘 要： | 以冰乙酸为溶剂,以5-叔丁基-2-羟基苯甲醛和溴素为原料,合成了3-溴-5-叔丁基-2-羟基苯甲醛。考察了溶剂、反应温度、物料比、反应时间等对3-溴-5-叔丁基-2-羟基苯甲醛收率的影响,合成的优化工艺条件为:n(5-叔丁基-2-羟基苯甲醛)∶n(溴素)=1∶1.1,反应温度60℃,反应时间10 h,在此工艺下,收率可达到88.2%,产品经MS、1H NMR确认。
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| 关 键 词： | 3-溴-5-叔丁基-2-羟基苯甲醛 合成 优化 |
Study on Synthesis of 3-Bromo-5-tert-butyl-2-hydroxy-benzaldehyde |
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| ZHANG Xing , HUI Jian-bin. Study on Synthesis of 3-Bromo-5-tert-butyl-2-hydroxy-benzaldehyde[J]. Fine Chemical Intermediates, 2012, 42(3): 17-20 |
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| Authors: | ZHANG Xing HUI Jian-bin |
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| Affiliation: | 1,2(1.Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190;2.Tangshan High-tech Research and Transformation Center,Chinese Academy of Sciences,Tangshan 063020) |
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| Abstract: | 3-Bromo-5-tert-butyl-2-hydroxy-benzaldehyde(BTHB)was synthesized from bromine and 5-tert-butyl-2-hydroxy-benzaldehyde(THB)in 88.2% yield in acetic acid.The reaction conditions were investigated and the optimal conditions were as followings:solvent of acetic acid,molar ratio of THB to bromine of 1.1 to 1,temperature of 60℃,reaction time of 10 h.The final product was characterized with 1H NMR. |
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| Keywords: | 3-bromo-5-tert-butyl-2-hydroxy-benzaldehyde synthesis optimization |
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