| 5-溴代胡椒环的合成方法研究 |
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| 引用本文： | 姜辉,赵素娟,赵巍,王海波,王海洋,王守凯. 5-溴代胡椒环的合成方法研究[J]. 精细化工中间体, 2012, 42(3): 47-49 |
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| 作者姓名： | 姜辉 赵素娟 赵巍 王海波 王海洋 王守凯 |
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| 作者单位： | 中钢集团鞍山热能研究院有限公司,辽宁鞍山,114044 |
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| 摘 要： | 以胡椒环为原料,采用氧化溴化体系合成5-溴代胡椒环,确定了溴化工艺条件,考察了溶剂种类、反应温度、物料配比及反应时间对反应的影响。优化工艺为:三氯甲烷为反应溶剂,反应温度为10℃,反应时间为6 h,物料配比n(胡椒环)∶n(氢溴酸)=1∶1.2。产品收率81%,产品纯度99.5%(GC)。产物的结构经1H NMR、IR、MS表征。
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| 关 键 词： | 溴代胡椒环 溴化 合成 |
Study on Synthesis of 5-Bromo-pepper Ring |
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| JIANG Hui , ZHAO Su-juan , ZHAO Wei , WANG Hai-bo , WANG Hai-yang , WANG Shou-kai. Study on Synthesis of 5-Bromo-pepper Ring[J]. Fine Chemical Intermediates, 2012, 42(3): 47-49 |
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| Authors: | JIANG Hui ZHAO Su-juan ZHAO Wei WANG Hai-bo WANG Hai-yang WANG Shou-kai |
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| Affiliation: | (Sinosteel Anshan Research Institute of Thermo-Energy Co.,Ltd.Anshan 114044,China) |
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| Abstract: | 5-Bromo-pepper ring was synthesized from pepper ring by its bromination with H2O2/HBr or bromine.The reaction conditions of the H2O2/HBr system were investigated.The optimum conditions were as followings:chloroform as the reaction solvent,reaction temperature of 10℃,reaction time of 6 hours,molar ratio of pepper ring to hydrogen bromide of 1.0∶1.2.The target product was obtained in 81% yield(purity 99.5% GC)and its structure was confirmed with IR,1H NMR and MS. |
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| Keywords: | 5-bromo-pepper ring bromination synthesis |
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