| 反-4-(5'-丙基-四氢吡喃-2'-基)-环己基甲酸的合成 |
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| 引用本文： | 何汉江,高丰琴,郭强,王小明,张明雨.反-4-(5'-丙基-四氢吡喃-2'-基)-环己基甲酸的合成[J].精细化工,2012,29(4):410-412,416. |
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| 作者姓名： | 何汉江 高丰琴 郭强 王小明 张明雨 |
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| 作者单位： | 1. 西安瑞联近代电子材料有限责任公司,陕西西安,710075
2. 咸阳师范学院,陕西咸阳,712000 |
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| 摘 要： | 以反-4-(5'-丙基-四氢吡喃-2'-基)-苯甲酸(3PyPA)为原料,经催化加氢合成顺/反-4-(5'-丙基-四氢吡喃-2'-基)-环己基甲酸(3PyHA)混合物。加氢条件实验表明,以Ru/C为催化剂,以NaOH水溶液为反应介质,当反应温度为75～85℃,压力为3.5 MPa时反应效果最佳。加氢完粗品经高温异构化反应,甲苯乙醇混合溶剂重结晶得色谱纯度99.5%以上的反-3PyHA。
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| 关 键 词： | 反-4-(5'-丙基-四氢吡喃-2'-基)-环己基甲酸 加氢 异构化 精细化工中间体 |
Synthesis of trans-4- (5'-Propyl-tetrahydropyran-2'-yl) -cyclohexane Carboxylic Acid |
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| HE Han-jiang
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GAO Feng-qin
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GUO Qiang
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WANG Xiao-ming
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ZHANG Ming-yu.Synthesis of trans-4- (5'-Propyl-tetrahydropyran-2'-yl) -cyclohexane Carboxylic Acid[J].Fine Chemicals,2012,29(4):410-412,416. |
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| Authors: | HE Han-jiang GAO Feng-qin GUO Qiang WANG Xiao-ming ZHANG Ming-yu |
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| Affiliation: | 1(1.Xi′an Ruilian Modern Electronic Materials Co.,Ltd,Xi′an 710075,Shaanxi,China;2.Xianyang Normal University,Xianyang 712000,Shaanxi,China) |
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| Abstract: | The mixtures of cis/trans-4-(5′-propyl-tetrahydropyran-2′-yl)-cyclohexane carboxylic acid(3PyHA) were synthesized from trans-4-(5′-propyl-tetrahydropyran-2′-yl)-benzoic acid(3PyPA) by catalytic hydrogenation.The results of hydrogenation condition experiments show that the reaction results were best with Ru/C as catalyst,NaOH solution as reaction medium,and when the reaction temperature was 75～85 ℃ and hydrogenation pressure was 3.5 MPa.A purity of more than 99.5% of trans-4-(5′-propyl-tetrahydropyran-2′-yl)-cyclohexane carboxylic acid(3PyHA) can be obtained by isomerization reaction with high temperature and subsequently by recrystallization with toluene and ethanol. |
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| Keywords: | trans-4-(5′-propyl-tetrahydropyran-2′-yl)-cyclohexanecarboxylic acid hydrogenation isomerization fine chemical intermediates |
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