| 合成2-(2-氨基-4-噻唑)-2-(甲氧羰基甲氧亚胺基)乙酸顺反异构体的研究 |
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| 引用本文： | 厉昆,江海波,付凌燕,任红阳.合成2-(2-氨基-4-噻唑)-2-(甲氧羰基甲氧亚胺基)乙酸顺反异构体的研究[J].精细化工中间体,2012,42(3):52-54. |
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| 作者姓名： | 厉昆 江海波 付凌燕 任红阳 |
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| 作者单位： | 1. 浙江普洛得邦制药有限公司,浙江东阳,322118
2. 山东普洛得邦医药有限公司,山东潍坊,262737 |
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| 摘 要： | 以4-氯代-2-甲氧羰基甲氧亚胺基-3-氧代丁酸(CMOBA)为原料,通过控制反应体系的pH值,分别合成出高选择性的顺式2-(2-氨基-4-噻唑)-2-(甲氧羰基甲氧亚胺基)乙酸(简称(MICA)及反式MICA产物,用高效液相色谱、熔点和红外光谱对产物的结构和纯度进行了分析。并对形成顺、反异构体的机理进行了探讨。
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| 关 键 词： | pH值 顺、反异构 机理 |
Study on the Synthesis of Cis-trans Isomerism of 2-(2-Aminothiazole-4-yl)-2-(methoxy carboxyl methoxy amino)acetic Acid |
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| LI kun
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JIANG Hai-bo
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FU Ling-yan
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REN Hong-yang.Study on the Synthesis of Cis-trans Isomerism of 2-(2-Aminothiazole-4-yl)-2-(methoxy carboxyl methoxy amino)acetic Acid[J].Fine Chemical Intermediates,2012,42(3):52-54. |
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| Authors: | LI kun JIANG Hai-bo FU Ling-yan REN Hong-yang |
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| Affiliation: | 1(1.Zhejiang Apeloa Tospo Pharm.Co.,LTD.,Dongyang 322118,China;2.Shandong Apeloa Tospo Pharm.Co.,LTD.,Weifang 262737,China) |
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| Abstract: | By controlling the pH of reaction system,high selectivity of cis-MICA and trans-MICA were synthesized from 4-chloro-2-methoxy carboxyl methoxy amino-3-oxbutyric acid(CMOBA).The structure and purity of the product were characterized by means of HPLC、MP and IR.Also,the mechanism of formation cis-trans isomerism was discussed. |
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| Keywords: | pH cis-trans isomerism mechanism |
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