Biocompatibility,physico-chemical and mechanical properties of hydroxyapatite-based silicon dioxide nanocomposites for biomedical applications |
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| Affiliation: | 1. State Key Lab of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan, 430070, China;2. Key Laboratory of Fiber Optic Sensing Technology and Information Processing, Ministry of Education, Wuhan University of Technology, Wuhan, 430070, China;3. Materials Research Institute, The Pennsylvania State University, University Park, PA16802, USA;1. Department of Physics, K.S. Rangasamy College of Arts and Science (Autonomous), Tiruchengode 637215, Tamil Nadu, India;2. Department of Functional Nanosystems and High-Temperature Materials, National University of Science and Technology “MISiS”, Leninskiy Pr. 4, Moscow 119049, Russia;3. Department of Biotechnology, K.S. Rangasamy College of Arts and Science (Autonomous), Tiruchengode 637215, Tamil Nadu, India;4. Department of Physics, Periyar University, Salem 636011, Tamil Nadu, India;5. Department of Physical Materials Science, National University of Science and Technology “MISiS”, Leninskiy Pr. 4, Moscow 119049, Russia;1. Department of Chemistry, Vellore Institute of Technology, Vellore, Tamilnadu 632014, India;2. Centre for Biomaterials, Cellular and Molecular Theranostics (CBCMT), Vellore Institute of Technology, Vellore, Tamilnadu 632014, India;3. School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamilnadu 632014, India;1. VTU Research Resource Centre, Visvesvaraya Technological University, Belagavi 590018, Karnataka, India;2. Rajarambapu Institute of Technology, Islampur, Sangli 415414, Maharashtra, India;3. Center for Interdisciplinary Research, D. Y. Patil University, Kolhapur 416006, India;4. Department of Materials Science & Engineering, University of Seoul, 130-743, South Korea;5. Tontadarya College of Engineering, Gadag 582101, Karnataka, India;6. Department of Chemistry, Lal Bahadur Shastri College, Satara 415002, Maharashtra, India;7. Department of Materials Science and Engineering, Chonnam National University, Gwangju 500-757, South Korea;8. Ultra-Precision Optics Research Center, Korea Photonics Technology Institute (KOPTI), Cheomdanventure-ro, Gwangju 500-779, South Korea;1. Technological Institute of Saltillo, TecNM, Graduate Division, Saltillo 25280, Mexico;2. Center for Research and Advanced Studies of the NPI, Campus Saltillo, Saltillo 25900, Mexico;3. Research Laboratory of Hydrothermal Chemistry, Faculty of Science, Kochi University, Kochi 780-8520, Japan |
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| Abstract: | High-energy ball milling was employed to prepare carbonated hydroxyapatite/silicon dioxide (CHA/SiO2) nanocomposites. Then, these nanocomposite powders were sintered at 900 and 1300 °C. XRD technique, FTIR spectroscopy and SEM were employed to examine the structure, molecular structure and microstructure of the sintered nanocomposites samples, respectively. Moreover, their mechanical properties were also measured. Furthermore, in vitro bioactivity and cytotoxicity of these nanocomposites were evaluated. The results indicated that the successive increases in SiO2 contents led to remarkable enhancement for densification behavior, mechanical properties and in vitro bioactivity of nanocomposites sintered at 900 °C. However, further increase in the sintering temperature to 1300 °C caused dramatic decreases in density and mechanical properties of nanocomposites. On the contrary, better bioactivity behavior was achieved. Amazingly, the obtained results revealed that the sample having the highest content of SiO2 and sintered at 900 °C had no toxic effects on bone-like cells while, that sintered at 1300 °C exhibited mild cytotoxicity. Based on the variations in the abovementioned properties, these nanocomposites can be used in different biomedical applications. |
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| Keywords: | Bioactivity Physico-chemical properties Mechanical properties Hydroxyapatite-silica nanobiocomposites Biomedical applications |
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