Synthesis method of novel Gd2O3@Fe3O4 nanocomposite modified by dextrose capping agent |
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| Affiliation: | 1. Polymer Material Department, School of Chemical Engineering, Guangdong University of Petrochemical Technology, Maoming, China;2. Division of Energy and Environment, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China;3. Department of Mathematics, University of Gujrat, Gujrat 54700, Pakistan;4. Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China;5. College of Electronic Science and Technology of Shenzhen University, THz Technical Research Center of Shenzhen University, Key Laboratory of Optoelectronics Devices and Systems of Ministry of Education and Guangdong Province Shenzhen University, Shenzhen 518060, China;6. Materials Science and Engineering, Shenzhen Graduate School, Harbin Institute of Technology, Shenzhen 518055, China;1. Duy Tan University, 182 Nguyen Van Linh, Da Nang, Viet Nam;2. Institute of Materials Science, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam;3. Graduate University of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam;4. Institute of Low Temperature and Structure Research, Polish Academy of Science, Ul.Okolna 250-422, Wroclaw, Poland;5. National Chung Cheng University, Ming Hsiung, Chia Yi 621, Taiwan;1. Department of Chemistry and Department of Nanoscience and Nanotechnology (DNN), College of Natural Sciences, Kyungpook National University (KNU), Taegu 41566, South Korea;2. Department of Molecular Medicine and Medical & Biological Engineering and DNN, School of Medicine, KNU and Hospital, Taegu 41566, South Korea;3. Department of Biology Education and DNN, Teachers’ College, KNU, Taegu 41566, South Korea;1. Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Sciences, Health Science Center, Xi''an Jiaotong University, Xi''an, Shaanxi 710061, China;2. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, Fujian 361102, China;3. School of Materials Science and Engineering, Sun Yat-sen University, Guangzhou, Guangdong 510275, China;4. The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi''an Jiaotong University, Xi''an, Shaanxi 710049, China;5. College of Medical Technology, Shanghai University of Medicine & Health Sciences, Shanghai 201308, China;6. College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou, Zhejiang 310018, China;1. Department of Materials Science and Engineering, Sharif University of Technology, Iran;2. Biomolecular Image Analysis Group, Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Iran;3. Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Iran;4. Department of Materials Engineering, Tarbiat Modares University, Tehran, PO Box 14115-143, Iran |
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| Abstract: | In current study, gadolinium oxide was heterogeneously formed on the surface of iron oxide nanoparticles and further modified with dextrose capping agent to be used in biomedical applications, especially for contrast enhancement in MR images. First, two types of iron oxide nanoparticles were prepared at 25 and 80 °C via simple coprecipitaion method. Then, gadolinium oxide nanoparticles were synthesized through a consecutive precipitation process on previously formed iron oxide seeds in an aqueous media and subsequent annealing at 300 °C. Finally, dextrose was used as capping agent to stabilize nanocomposites in a colloidal suspension. X-ray diffraction (XRD), Scanning and Transmission electron microscopy, Dynamic Laser Scattering (DLS), Fourier-Transform Infrared Spectroscopy (FTIR), and Magnetometery (VSM) techniques were employed for nanocomposites investigation and MTT-assay method used for viability assessment of colloidal samples. Measurements based on Scherrer equation from XRD patterns showed that increasing coprecipitation temperature resulted bigger iron oxide crystallites. The iron oxide crystallite size was increased from 15.1 to 28.1 nm. Precipitation process led to gadolinium oxide formation with 30.7 and 38.8 nm crystallite sizes, respectively. TEM images revealed that iron oxide agglomerates were encapsulated in gadolinium oxide surroundings. Hydrodynamic size of the coated nanoparticles with dextrose was 208 and 247 nm. In VSM examinations, nanocomposites did not display coercive field and the saturation magnetization was 1.93 emu/g. MTT-assay results showed 80% viability in 285 μg nanocomposites containing 96.9 μg [Fe] and 11.4 μg [Gd]. |
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| Keywords: | Nanocomposites Powders: chemical preparation Magnetic properties Gadolinium oxide |
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