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Synthesis,characterization and in-vitro bioactivity evaluation of mesoporous Ca10-xFex(PO4)6(OH)2 nanorods-like particles
Affiliation:1. Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary;2. Department of Biophysics and Radiation Biology, Semmelweis University, MTA-SE Molecular Biophysics Research Group, Budapest, Hungary
Abstract:Multifunctional nanomaterials with superior super-paramagnetic and bioactivity properties with regulated particle morphology can be advantageous for several therapeutic applications. In this investigation, nanorods-like mesoporous particles of Ca10-xFex(PO4)6(OH)2 with varying concentrations of Fe ions were hydrothermally synthesized. In addition to the evaluation of structural and physicochemical properties, magnetic and in-vitro bioactivity attributes were further investigated. Results suggested that with increasing concentration of Fe ions; lattice parameters, crystal size and crystallinity decreased, whereas, surface area, porosity and magnetization of nanorods-like mesoporous particles increased. Nanocomposites exhibited superior super-paramagnetic property. Particles were bioactive and non-resorbable in simulated conditions. Thus, the amalgamation of super-paramagnetism with superior textural and bioactive properties of nanoparticles suggested their high potential for multifunctional applications, including anti-cancer hyperthermia treatment, drug delivery and tissue regeneration.
Keywords:Hydroxyapatite  Super-paramagnetic  Mesoporous  Nanorods  Hyperthermia
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