Stability and cytotoxicity study of NiFe2O4 nanocomposites synthesized by co-precipitation and subsequent thermal annealing |
| |
| Affiliation: | 1. West University of Timisoara, Faculty of Physics, Bd.V. Parvan, No. 4, 300223 Timisoara, Romania;2. National Institute for Research and Development in Electrochemistry and Condensed Matter, 300569 Timisoara, Romania;3. Politehnica University of Timisoara, Piata Victoriei 2, 300006 Timisoara, Romania;1. Department of Mechanical Engineering, Faculty of Engineering and Technology (FET), International Islamic University (IIU), Islamabad, 44000, Pakistan;2. Materials Research Laboratory, Department of Physics, Faculty of Basic and Applied Sciences (FBAS), International Islamic University (IIU), Islamabad, 44000, Pakistan;3. National University of Sciences and Technology (NUST), Islamabad, Pakistan;4. National Engineering and Scientific Commission, Islamabad, Pakistan;1. Federal Technological University of Paraná, UTFPR, Avenida dos Pioneiros 3131, 86036-370, Londrina, PR, Brazil;2. Instituto de Magnetismo Aplicado, UCM-ADIF-CSIC, A6 22,500km, 28230 Las Rozas, Spain;3. Dto. Física Materiales, UCM, Ciudad Universitaria, 28040 Madrid, Spain;4. Department of Physics, Pontificia Universidade Catolica do Rio de Janeiro, Rio de Janeiro 22451-900, Brazil;5. Departamento de Química, UFSCar, PO Box 676, 13565-905 São Carlos, SP, Brazil;1. Physics Department, College of Science and Arts, Jouf University, P.O. Box 756, Al-Gurayyat, Saudi Arabia;2. Physics and Engineering Mathematics Department, Faculty of Electronic Engineering, Menoufia University, Menouf 32952, Egypt;3. Solid State Electronics Laboratory, Solid State Physics Department, Physics Division, National Research Centre, 33 El Bohouth St., Dokki, Giza P.O.12622, Egypt;4. Physics Department, Faculty of Science, South Valley University, Qena, Egypt |
| |
| Abstract: | In this article, NiFe2O4 nanoparticles (NPs) were prepared by co-precipitation method with subsequent thermal annealing leading to obtainment NPs with average sizes of 78 nm. Structure and magnetic analysis were performed by X-ray diffraction, transmission electron microscopy, Mössbauer spectroscopy and vibrating sample magnetometry techniques. Stability of NiFe2O4 NPs was evaluated in PBS solution during 20 days. The toxicity of prepared NPs was evaluated in vitro using different cancer cell lines: HeLa (cervical cancer cell), PC-3 (prostate cancer cell). Fibroblasts like cells of L929 obtained from subcutaneous adipose tissue of mouse were used as normal cells. Results indicate successful synthesis of NiFe2O4 NPs that exhibit low cytotoxicity in concentration range from 1 to 100 μg/ml. Presented physical and biological results indicate the possibility of application investigated magnetic nanoparticles in hyperthermia, targeted drug delivery, magnetic resonance imaging or cell separation. |
| |
| Keywords: | Ferrites Magnetic nanocomposites In vitro study Thermal annealing Stability in PBS solution |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
