| 电喷雾串联质谱监测合成帕拉米韦的反应副产物 |
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| 引用本文： | 陈良柱,方炳虎,陈建新,杨利军. 电喷雾串联质谱监测合成帕拉米韦的反应副产物[J]. 质谱学报, 2008, 29(Z1): 157-159 |
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| 作者姓名： | 陈良柱 方炳虎 陈建新 杨利军 |
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| 作者单位： | 1. 华南农业大学兽医学院，广东 广州 510642；2. 广东大华农动物保健品股份有限公司，广东 新兴 527439 |
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| 摘 要： |
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Detection of Products Formed in Side Reactions in Peramivir Synthesis with Electrospray Ionization-Mass Spectrometry |
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| CHENLiang-zhu,FANGBing-hu,CHENJian-xin,YANGLi-jun. Detection of Products Formed in Side Reactions in Peramivir Synthesis with Electrospray Ionization-Mass Spectrometry[J]. Journal of Chinese Mass Spectrometry Society, 2008, 29(Z1): 157-159 |
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| Authors: | CHENLiang-zhu FANGBing-hu CHENJian-xin YANGLi-jun |
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| Affiliation: | 1. College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China;
2. Guangdong Dahuanong Animal Health Products Stock Co.,Ltd., Xinxing 527439, China
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| Abstract: | Electrospray ionization mass spectrometry (ESI-MS) and collisional activation technology were used to determine target compound and monitor key intermediates in peramivir synthesis, a novel anti-influenza virus agent. Chemical structure of impurity formed in the last step were identified to be dehydroxylation product of peramivir based on ESI-MS and MS2. Dehydroxylation product of peramivir was origined the side reaction of hydrolization of intermediate (5). |
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| Keywords: | electrosprayionization-massspectrometry collisionalactivation peramiversynthesis sidereactionproduct |
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