Unsupervised segmentation of noisy and inhomogeneous images using global region statistics with non-convex regularization

Improving the segmentation of magnetic resonance (MR) images remains challenging because of the presence of noise and inhomogeneous intensity. In this paper, we present an unsupervised, multiphase segmentation model based on a Bayesian framework for both MR image segmentation and bias field correction in the presence of noise. In our model, global region statistics are utilized as segmentation criteria in order to classify regions with similar mean intensities but different variances. Additionally, we propose an edge indicator function based on a guided filter (instead of a Gaussian filter) that can preserve the underlying edges of the image obscured by noise. The proposed edge indicator function is integrated with non-convex regularization to overcome the influence of noise, resulting in more accurate segmentation. Furthermore, the proposed model utilizes a Markov random field to model the spatial correlation between neighboring pixels, which increases the robustness of the model under high-noise conditions. Experimental results demonstrate significant advantages in terms of both segmentation accuracy and bias field correction for inhomogeneous images in the presence of noise.