Combination of vegetable soup and glucan demonstrates synergistic effects on macrophage-mediated immune responses |
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| Authors: | Ha-Nul Lee Joo-Hee Choi Ji-Yeon Park Jae-Hun Ahn Da Eun Jang Jae Gun Shim Jong-Hwan Park Young-Min Kim |
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| Affiliation: | 1.Department of Integrative Food, Bioscience and Biotechnology, Chonnam National University, Gwangju, 61186 Republic of Korea ;2.Laboratory Animal Medicine, College of Veterinary Medicine, Chonnam National University, Gwangju, 61186 Republic of Korea ;3.Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, 41061 Republic of Korea ;4.Charmden Health Sciences Agricultural Co. 152, Nanosandan-ro, Jinwon-myeon, Jangseong-gun, Jeollanam-do Republic of Korea |
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| Abstract: | Vegetable soup (VS), a plant-based functional food, has been used as a traditional folk medicine and is attracting attention for its ability to enhance the immune response. β-Glucan, a well-established and effective immunomodulator, has synergistic effects when used in combination with some bioactive compounds. In the present study, we aimed to evaluate the synergistic immunomodulatory effects of the combination of VS and β-glucan on macrophage-mediated immune responses. β-Glucan was demonstrated to synergistically enhance the VS-stimulated immune response, including the production of interleukin-6, tumor necrosis factor-α, and nitric oxide, mainly through the mitogen-activated protein kinase pathway in macrophages. In addition, this combination has the potential for further development in functional foods with immune-enhancing activity.Supplementary InformationThe online version contains supplementary material available at 10.1007/s10068-021-00888-x. |
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| Keywords: | Vegetable soup, β -glucan, Synergistic effect, Mitogen-activated protein kinase, Immune response |
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