| 4-氨基-7-氯-5-氟-2,3-二氢-2-甲基苯并呋喃的合成研究 |
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| 引用本文： | 王俊春,郭同娟,宋迎霞,王作斌. 4-氨基-7-氯-5-氟-2,3-二氢-2-甲基苯并呋喃的合成研究[J]. 现代农药, 2003, 2(2): 18-19 |
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| 作者姓名： | 王俊春 郭同娟 宋迎霞 王作斌 |
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| 作者单位： | 大连瑞泽农药股份有限公司研究所,辽宁大连,116100 |
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| 摘 要： | 4-氨基-7-氯-5-氟-2,3-二氢-2-甲基苯并呋喃是合成除草剂的中间体。它通过以下途径制得:4-氯-2-氟-5-羟基-苯基氨基羧酸乙酯经醚化、水解、转位、闭环制得产品,总收率为21.7%,产品结构经核磁共振氢谱确认。
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| 关 键 词： | 醚化 水解 转位 闭环 |
| 修稿时间： | 2003-02-17 |
Synthesis of 4-Amino-7-chloro-5-fluoro-2,3- dihydro-2-methylbenzofuran |
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| Wang Junchun Guo Tongjuan Song Yingxia et al.. Synthesis of 4-Amino-7-chloro-5-fluoro-2,3- dihydro-2-methylbenzofuran[J]. Modern Agrochemicals, 2003, 2(2): 18-19 |
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| Authors: | Wang Junchun Guo Tongjuan Song Yingxia et al. |
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| Abstract: | Amino-7-chloro-5-fluoro-2,3-dihydro-2-methl- benzofuran is the intermediate for the synthesis of some new herbicide. The chemical route for the synthesis of the compound is as follows: ethyl 4-chloro-2-fluoro-5-hydroxy- phenyl amino-carboxylate is etherified at first, and then hydrolyzed, transformed, and cyclized to obtain the above compound. The total yield is 21.7% from the starting material. The chemical structure has been identified by NMR. |
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| Keywords: | benzofuran etherification hydrolysis transformation cyclization |
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