Cation exchange resin catalyzed hydroamination of vinylpyridines with aliphatic/aromatic amines

A simple and efficient protocol has been developed for hydroamination of vinylpyridines catalyzed by cation exchange resins as a heterogeneous, recyclable and environmentally benign catalyst under milder reaction conditions. The catalytic activity of various macroreticular/gel type cation exchange resin was evaluated and Amberlyst-15/Nafion-NR50 were found to provide yields in the range of 90%. The protocol was successfully applied for pyridylethylation of wide variety of aryl/alkyl amines having different steric and electronic properties.