脂质组学在糖尿病及其并发症早期诊断和治疗中的作用

糖尿病早期无任何症状,或仅伴有轻度乏力、不适、口渴等不明显症状,但糖尿病的诊断标准仅血糖一项,较为单一,并且早期病变期的患者血糖指数变化并不明显,往往在发生严重并发症时才察觉。脂质组学的发展,能够通过对糖尿病患者和健康人群的血浆脂质组分的检测、比较,建立更为全面、准确的糖尿病病前诊断和病后治疗效果的评价标准。综述了脂质组学在糖尿病及其并发症诊断和治疗中的作用,总结了糖尿病诊断过程中的主要脂质标志物,探究了膳食结构和药物对糖尿病患者血浆中脂质标志物种类和数量变化的影响。

Role of lipidomics in early diagnosis and therapy of diabetes and its complications

Diabetes may occur with no symptoms or some non-obvious symptoms, such as mild fatigue, malaise and thirst. The diagnostic criteria for diabetes is only blood glucose, which is relatively single. In addition, the changes of the glycemic index in patients in the early stage of diabetes are not obvious until serious complications have arisen. With the development of lipidomics, more comprehensive and accurate assessment criteria for diagnosis and treatment effect of diabetes are established via determining and comparing the plasma lipid composition of diabetics and healthy individuals. The role of lipidomics in early diagnosis and therapy of diabetes and its complications was summarized. Moreover, the diagnostic biomarkers of diabetes and its complications and the effect of dietary structure and drugs on the type and content of biomarker were also summarized.