| Abstract: | A prepolymerization process was used to prepare functionalized poly(N‐isopropylacrylamide) latexes with surface cyano groups. The functionalized latexes prepared were characterized by FTIR, 1H NMR, scanning electron microscopy and quasi‐elastic light scattering. In addition, the polymerization conversion and the water‐soluble polymer amounts were quantified. The polymerization conversions were found to be above 80% with 5–14 wt% of water soluble polymer formation. The immobilization of antibody (immunoglobulin) onto such cyano‐containing thermally sensitive particles, suggests the feasibility of specific dipole–dipole interactions between the cyano and hydroxyl functional groups from particle and antibody, respectively. Copyright © 2004 Society of Chemical Industry |
