| NASOPHARYNGEAL CARCINOMA RADIOSENSITIVITY PREDICTION BY CYTOKINESIS－BLOCK MICRONUCLEUS ASSAY |
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| 引用本文： | 杨星,史剑慧,程文英.NASOPHARYNGEAL CARCINOMA RADIOSENSITIVITY PREDICTION BY CYTOKINESIS－BLOCK MICRONUCLEUS ASSAY[J].核技术(英文版),1995(1). |
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| 作者姓名： | 杨星 史剑慧 程文英 |
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| 作者单位： | Shanghai Institute of Radiation Medicine，Shanghai Medical University，Shanghai 200032 |
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| 摘 要： | ＮＡＳＯＰＨＡＲＹＮＧＥＡＬ ＣＡＲＣＩＮＯＭＡ ＲＡＤＩＯＳＥＮＳＩＴＩＶＩＴＹ ＰＲＥＤＩＣＴＩＯＮ ＢＹ ＣＹＴＯＫＩＮＥＳＩＳ－ＢＬＯＣＫ ＭＩＣＲＯＮＵＣＬＥＵＳ ＡＳＳＡＹＹａｎｇＸｉｎｇ（杨星）；ＳｈｉＪｉａｎｈｕｉ（史剑慧）ａｎｄＣｈ...
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NASOPHARYNGEAL CARCINOMA RADIOSENSITIVITY PREDICTION BY CYTOKINESIS-BLOCK MICRONUCLEUS ASSAY |
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| Yang Xing, Shi Jianhui and Cheng Wenying.NASOPHARYNGEAL CARCINOMA RADIOSENSITIVITY PREDICTION BY CYTOKINESIS-BLOCK MICRONUCLEUS ASSAY[J].Nuclear Science and Techniques,1995(1). |
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| Authors: | Yang Xing Shi Jianhui and Cheng Wenying |
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| Abstract: | Cytokinesis-block micronucleus method is used to evaluate the radiosensitivity of a nasopharyngeal carcinoma cell line (CNE-1) and biopsies obtained from 31 patients with nasopharyngeal carcinoma. The number of micronuclei increases with theradiation dose. A good correlation was found between the radiosensitivity determined by the micro-nucleus assay and that measured by the colony-forming assay in CNE-1 cell line (r=-0.998). Moreover, the results of micronucleus assay for tumor cells from biopsies of patients with primary carcinoma look promising for the prediction of tumor radiosensitivity. These results are encouraging but fleed to be confirmed with a larger number of patients with a longer follow-up. |
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| Keywords: | Micronucleus assay Radiosensitivity Nasopharyngeal carcinoma |
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