The effect of neurotensin on the concentration of cholesterol and bile acids in the guinea pig |
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Authors: | Ludvik Peric-Golia Clark F Gardner Dana E Wilson Milena Peric-Golia |
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Affiliation: | (1) Veterans Administration Medical Center, 84148 Salt Lake City, UT;(2) Departments of Pathology and Medicine, University of Utah School of Medicine, 84132 Salt Lake City, UT |
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Abstract: | In guinea pigs, total plasma cholesterol concentrations increased above the control values after single intravenous injections
and after 3 days of continuous subcutaneous administration of neurotensin (NT). A high dose of NT (125 pmol/100 g body weight)
induced tachycardia and severe respiratory distress; the lowest dose (1.25 pmol/100 g body weight) had the greatest hypercholesterolemic
effect 15 min after the injections. The bulk of the total plasma cholesterol was in low density lipoprotein fractions. Cholesterol
increased in the same fractions after intravenous administrations of NT. NT induced a decrease in the cholesterol content
in the ileum but did not affect significantly the cholesterol content in the liver, kidneys or adrenals. In 48-hr fasted controls,
plasma cholesterol concentration and cholesterol content in the liver, kidneys, adrenals and terminal ileum increased; after
intravenous injections of NT, plasma cholesterol concentration further increased but cholesterol content of the liver, kidneys
and ileum decreased. In fed animals, the concentration of the biliary taurochenodeoxycholic acid increased above the control
values 5 and 35 min after the intravenous injections of NT. In fasted controls, the total concentration of bile acids was
higher than in fed controls, but only the concentration of taurochenodeoxycholic acid further increased after the injections
of NT. Proportionately more taurochenodeoxycholic acid than cholesterol was present in bile after the intravenous injections
of NT. These data are consistent with the hypothesis that NT has a regulatory role in intestinal cholesterol transport. |
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