An efficient method for synthesis of some heterocyclic compounds containing 3-iminoisatin and 1,2,4-triazole using Fe3O4 magnetic nanoparticles |
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| Authors: | Navabeh Nami Daryoush Zareyee Maryam Ghasemi Ameneh Asgharzadeh Mehdi Forouzani Somayeh Mirzad |
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| Affiliation: | 1. Department of Chemistry, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran;2. Department of Chemistry, Payam Noor University, Sari Branch, Sari, Iran |
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| Abstract: | 1,2,4-triazole derivatives were prepared by reaction of thiocarbohydrazide and some esters in 60% ethanol. Condensation of 1,2,4-triazole derivatives with isatin gave Schiff bases of 3-iminoisatin derivatives. Reaction of malonic or succinic acid dihydrazide with isatin lead to formation of N,N'-bis-(3-imino-1,3-dihydro-indolyl-2-one)-malonamide 8a and N,N'-bis-(3-imino-1,3-dihydro-indolyl-2-one)succinamide 8b in good yields under mild reaction conditions. These reactions are catalyzed by Fe3O4 MNPs. The chemical structures were confirmed by Fourier transform-infrared, 1H-NMR, 13C-NMR, gas chromatography-mass spectrometry spectroscopy, and elemental analysis. |
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| Keywords: | Fe3O4 magnetic nanoparticles therphthalic acid ethyl ester malonic dihydrazide succinic dihydrazide thiocarbohydrazide 3-iminoisatin 1,2,4-triazole |
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