A green and efficient synthesis of 2-thioxoquinazolinone derivatives in water using potassium thiocyanate |
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| Authors: | Ghasem Rezanejade Bardajee Aseyeh Ghaedi Shohreh Hekmat Ghazale Abarashi Mohammad Mahdavi |
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| Affiliation: | 1. Department of Chemistry, Payame Noor University (PNU), Tehran, Iran;2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran |
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| Abstract: | Green chemistry is one of the most important routes for the synthesis of heterocyclic compounds. In this regard, the synthesis of 2-thioxoquinazolinone derivatives was achieved by condensation of versatile materials including isatoic anhydride, amine and potassium thiocyanate in the green medium of water. This convenient and ef?cient method affords the desired products with good to excellent yields. |
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| Keywords: | Thioxoquinazolinone green chemistry water isatoic anhydride potassium thiocyanate |
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