Controlled surface modification of Ti6Al4V using biomimetic mineralization via thermo-chemical route improves bioactivity |
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Affiliation: | 1. Department of Mechanical Engineering, National Institute of Technology, Rourkela, Odisha, 769008, India;2. Graduate School of Science and Technology, Yamagata University, 4-3-16, Jonan, Yonezawa, Yamagata, 992-8510, Japan;3. Department of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, Odisha, 769008, India |
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Abstract: | Ti alloy (Ti6Al4V) sheets were bio-activated by a two-step thermo-chemical treatment followed by biomimetic mineralization. The samples were then characterized by standard techniques and evaluated of their mechanical properties, electrochemical corrosion potential and biological performance. The intermediate layer corresponding to thermo-chemical treatment displayed anatase TiO2 peaks and the final bio-mineralization resulted in a globular hydroxyapatite (HAP) layer. Thermo-chemical treatment yielded a two-fold increase (98.79% increment) in microhardness value, whereas, the biomimetically activated samples showed a very small decrease in the same owing to their ceramic behavior. The surface hydrophobicity of the bio-activated surface was found reduced significantly, might assist to facilitate improved cell adhesion. Electrochemical corrosion measurements exhibited an increase in corrosion potential and decrease in current density of the samples, suggested increased corrosion resistant. The surface coating on the Ti6Al4V sheet also demonstrated enhanced cytocompatibility as no toxic effect of the samples could be perceived to human keratinocyte cell line (HaCaT). Similarly, the samples showed higher hemocompatibility and enhanced bactericidal activity. Our study concluded that the surface coating of Ti6Al4V sheets significantly improved corrosion resistance and bioactivity of the substrates, which can be applied for various biomedical applications. |
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Keywords: | Biomimetic mineralization Thermo-chemical treatment Ti6Al4V Biocompatibility Hemocompatibility |
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