2,6-二甲基-4-羟甲基吡啶的合成

为了寻找一条合成2,6-二甲基-4-羟甲基吡啶的简单,经济的方法,本文以2,4,6-三甲基吡啶为原料,分别与间氯过氧苯甲酸、乙酸酐以及氢氧化钠经过3步反应,将原料从2,4,6-三甲基吡啶转变成相应的2,4,6-三甲基吡啶-N-氧化物、2,6-二甲基-4-羟甲基吡啶乙酸酯进而水解得到最终产物,总收率达51.2%。与文献合成方法相比,本法采用原料便宜,操作简单,收率高。

Preparation of(2,6-dimethylpyridin-4-yl)methanol

To find a feasible, economic synthetic method for （2,6 - dimethylpyridin - 4 - yl） methanol, 2,4,6 - trimethylpyridine as the raw material, by 3 steps to react with mCPBA, acetic anhydride and NaOH, 2,4,6 -trimethylpyridine - N - oxide, （2,6 - dimethylpyridin - 4 - yl） methyl acetate was formed, and finally the product of （2,6 - dimeth- ylpyridin - 4 - yl） methanol was in a total yield of 51.2 %. Comparison with the method of the literature, the synthetic route had the advantages of cheaper material, easy controlled reaction conditions and higher yield.