Effect of Formulation Variables on the Preparation and in Vitro-in Vivo evaluation of Cimetidine Release from Ethyl Cellulose Micropellets

Ethyl cellulose embedded prolonged release microparticles containing cimetidine was designed by dispersing the drug-ethyl cellulose mixture in acetone, into a medium of mineral oil and subsequent rigidization of the ethyl cellulose matrix. Significant reproducibility of the manufacturing process was observed. In vitro-in vivo correlation revealed the the dissolution process is the rate determining step in drug absorption and the significant in vivo efficiency of the dosage form is well expected.