木垛型壳聚糖多孔支架的磷酸化改性和仿生矿化

为提高壳聚糖支架材料的孔隙率及矿化程度, 通过磷酸化表面改性和仿生矿化制备了磷酸化(PCSW)和生物矿化(BMCW)木垛型壳聚糖多孔支架。FTIR结果显示, 壳聚糖分子中有磷酸根的引入。XRD结果表明, 矿化24 h后支架上形成结晶度较高的磷酸钙盐晶体, 矿化48 h后结晶度明显增加并形成单纯的羟基磷灰石(HA)结晶。SEM观察发现, 在支架的内外表面均致密地沉积了HA晶体层。压缩强度测试结果表明, 复合支架BMCW矿化48 h的压缩强度为(0.54±0.005) MPa, 压缩模量为(5.47±0.65) MPa, BMCW可用作非承重骨组织修复材料。

Phosphorylation and biomimetic mineralization of chitosan woodpile porous scaffolds

To improve the porosity and mineralization of chitosan scaffolds, the woodpile architecture of the scaffolds were constructed, which were then modified by surface phosphorylation(PCSW) and biomineralization(BMCW). FTIR results show that phosphate species are conjugated to chitosan molecules. XRD results demonstrate that phosphate crystals form after 24 h of biomineralization, and highly crystallized hydroxyapatites(HA) have been detected after 48 h. SEM show that layers of dense HA crystals deposite on both of the inner and outer surfaces of the scaffolds. The compressive strength and modulus of the BMCW after biomineralization 48 h are (0.54±0.005) MPa and (5.47±0.65) MPa, respectively, indicating that BMCW can be used as a promising material for non-load bearing bone repairs.