| 对抗菌药物防突变浓度及突变选择窗两概念的探讨与思索 |
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| 引用本文： | 黄瀚,刘世坤. 对抗菌药物防突变浓度及突变选择窗两概念的探讨与思索[J]. 金属学报, 2008, 13(1): 21-24 |
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| 作者姓名： | 黄瀚 刘世坤 |
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| 作者单位： | 1.湖南省医药学校, 长沙 410000, 湖南;2.中南大学湘雅医学院附三医院药剂科, 长沙 410013, 湖南 |
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| 摘 要： | 防突变浓度(MPC) 及突变选择窗(MSW) 是由Zhao X 等近几年提出的防耐药变异的新概念。结合文献, 本文对MPC 及MSW 几个相关问题进行了探讨, 并简单综述了抗菌药物防耐药变异应用策略。
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| 关 键 词： | 防突变浓度 突变选择窗 最低抑菌浓度 耐药变异 |
| 收稿时间： | 2007-09-25 |
| 修稿时间： | 2007-10-21 |
Discussion and considerations on the mutant prevention concentration and mutant selective window |
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| HUANG Han,LIU Shi-kun. Discussion and considerations on the mutant prevention concentration and mutant selective window[J]. Acta Metallurgica Sinica, 2008, 13(1): 21-24 |
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| Authors: | HUANG Han LIU Shi-kun |
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| Affiliation: | 1.Hunan Medical College, Changsha 410000, Hunan, China;2.Department of Pharmacy, Third Affiliated Hospital of Xiangya Medical College, Central South University, Changsha 410013, Hunan, China |
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| Abstract: | The mutant prevention concentration (MPC) and mutant selective window (MSW) were new conceptive theories of resistance mutantion preventation which were raised by Zhao X and Drlica K et al. In this paper, the conceptions of MPC and MSW and some could related issues were discussed. Finally how to prevent resistance mutantion was reviewed. |
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| Keywords: | mutant prevention concentration mutant selective window minimum inhibitory concentration resistance mutantion |
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