对临床药理学一些基本问题研究的思考

临床药理学是研究药物与人体相互作用及其规律的一门学科。临床药理学基本原理在药物的临床研究与评价、药物不良反应监测等方面做了大量工作,取得了明显进展。然而,对临床药理学的共性、关键性和前沿性的基本问题研究更应给予高度关注,在进一步做好常规性临床药理学服务工作的同时,积极加强临床药理学学术问题的探索,为临床安全有效合理用药提供理论支撑。药物相互作用、多药耐药(MDR)、遗传药理学、药物基因组学、药动学/药效学(PK/PD)模型、性别药理学、基于药物作用于人体病理组织细胞的药效学和分子机制的研究等临床药理学的共性、关键性和前沿性问题已引起人们的重视。本文就临床药理学研究的一些基本问题的思考作一简述。

Consideration of research on some basic problems of clinical pharmacology

Clinical pharmacology is a subject to study the interactions and rules between drugs and the body .Principles of clinical pharmacology have made significant progress in many aspects, such as clinical trials, and evaluation of new drugs adverse drug reaction monitoring .Much importance should be attached to the study of common, critical and advanced questions in clinical pharmacology .Besides doing the rou-tine service of clinical pharmacology, exploration on academic research should also be strengthened to provide theoretical support to ensure the safety, effectiveness and rationality of clinical drug application .Study on drug interaction, multidrug resistance, pharmacogenetics, pharmacogenomics, PK/PD model, sex phar-macology, pharmacodynamics and molecular mechanism of drug based on pathological histiocyte of human body have attracted people' s attention.Consideration of research on some basic problems of clinical pharmacology were reviewed in this article .