槲皮素对非细菌性前列腺炎治疗作用的实验研究

目的: 观察槲皮素对实验性非细菌性前列腺炎的治疗效果。方法: 采用五种模型、包括消痔灵诱导的大鼠慢性前列腺炎模型、角叉菜胶诱导的急性前列腺炎模型、巴豆油致耳肿胀模型、光刺激致痛模型、棉球肉芽肿模型及体外测定离体家兔尿道平滑肌张力试验,观察槲皮素的作用。结果: 槲皮素对大鼠急慢性非细菌性前列腺炎具有良好的抗炎作用,对耳肿胀试验、肉芽肿试验及光刺激致痛试验具有良好的抑制作用,并对离体的尿道平滑肌具有较好的舒张作用。结论: 槲皮素对实验性非细菌性前列腺炎具有良好的抑制作用,并对尿道平滑肌具有一定舒张作用,提示槲皮素具有良好的临床治疗非细菌性前列腺炎作用,并能缓解排尿困难症状。

Experimental study on therapeutic effects of quercetin on abacterial prostatitis

AIM: To study the anti-inflammatory effects of quercetin on the experimental animal models of abacterial prostatitis.METHODS: Five types of experimental animal inflammatory models in vivo were applied to investigate the anti-inflammatory and analgesic effects of quercetin, including xiaozhiling-induced chronic prostatitis, carrageenan-induced acute prostatitis, croton oil-induced auricle swelling, photothermal stimulation-induced pain, cotton ball granuloma test of mice, and the rabbit urethral smooth muscle tensile test in vitro to examine the catabatic effects on dysuria.RESULTS: Quercetin displayed good anti-inflammatory effects on acute and chronic abacterial prostatitis. Quercetin also had good inhibitory effects on croton oilinduced auricle swelling, photothermal stimulation-induced pain and cotton ball granuloma test of mice and had definite relaxing effects on rabbit urethral smooth muscle.CONCLUSION: It indicates that quercetin has good therapeutic effects on abacterial prostatitis and could alleviate dysuria.