奥沙利铂联合氟尿嘧啶亚叶酸钙一线治疗转移性大肠癌2周方案与3周方案的对比研究

目的:比较奥沙利铂(L-OHP)联合5-氟尿嘧啶/亚叶酸钙(5-FU/CF)的2周方案与3周方案一线治疗转移性结直肠癌的临床疗效及不良反应。方法:66例转移性结直肠癌患者随机接受治疗。A 组, 予L-OHP 85 mg/m², 第1天, 静脉滴注2h, 同时或之后予CF 200 mg/m², 静脉滴注2h,续5-FU 400 mg/m², 静脉推注, 600 mg/m² 持续静脉滴注22h, 次日重复CF 与5-FU 。每2周重复1次, 每2次计为1周期。B 组, 予L-OHP130 mg/m², 第1天, 静脉滴注2h, CF 200 mg/m²,静脉滴注2h, 续5-FU 375～425 mg/m² 静脉滴注4～6h, 连用5d, 每3周重复1次, 每次计为1周期。结果:A 、B 两组疗效相近, RR 分别为42.9%和38.7%(P>0.05)。两组病例不良反应发生率相似, 主要表现为消化道反应、神经系统毒性和脱发。结论:L-OHP 联合5-FU/CF 的2周方案与3周方案均可作为晚期转移性大肠癌一线治疗的选择之一。

Comparison of 2-week regimen and 3-week regimen based on oxaliplatin plus 5-fluorouracil and Calcium folinate as the first-line in the reatment of metastatic colorectal cancer

AIM:To compare the efficacy and adverse reaction of oxaliplatin (L-OHP)in first-line chemotherapy of metastatic colorectal cancer(MCC)combined with infusional 5-fluorouracil (5-FU)and Calcium folinate (CF)administered every 2 weeks (FOLFOX4regimen)or every 3 weeks.METHODS:66previously untreated MCC patients were randomized in two chemotherapy regimen group :grouop A, oxaliplatin 85 mg/m² on first day, CF 200 mg/m² infusion 2h followed by bolus 5-FU 400 mg/m² and a 22h infusion of 5-FU 600 mg/m², repeated for 2consecutive days every 2 weeks.group B, oxaliplatin 130 mg/m² on first day, CF 200 mg/m² infusion 2h followed by a 4-6h infusion of 5-FU 375-425 mg/m², repeated for 5 consecutive days every 3 weeks.RESULTS:The two regimens have similar efficacy, the response rate of group A and B was 42.9% and 38.7% respectively (P>0.05).The adverse reaction rates of the two regimen were no statistical difference.CONCLUSION:The 2-week regimen and the 3-week regimen of L-OHP combined with 5-FU/CF have the same efficacy inMCC patients.