脑源性神经营养因子对离子通道的调节作用

脑源性神经营养因子(brain derived neuro-trophic factor, BDNF)是神经营养因子(neurotrophie factors,NTF)家族成员之一对中枢和周围神经系统多种神经元的生长、发育、分化、维持和损伤修复起重要作用。BDNF还能够调节神经元静息膜电位、神经兴奋性和突触传递,在突触可塑性过程中起重要作用,这些作用与其对离子通道的调节有关。BDNF不仅可以与THkB受体结合激活第二信使级联反应和蛋白磷酸化过程调节离子通道的性质,还可以直接调节钠通道活性。可见,BDNF还具有神经调质和兴奋性递质的作用。

Effects of brain derived neurotrophic factor on ion channel

Brain derived neurotrophic factor ( BD-NF) is one of the family of neurotrophic factors (NTF) which plays an important role in the growth, develop-ment, differentiation, maintenance and regeneration of various types of neurons in the CNS and PNS .BDNF also can affect the resting membrane potential of neu-rons, nervous excitation and synaptic transmission .It plays a critical role in the induction of synaptic plastic-ity .Many of these effects of BDNF are mediated by its modulation of ion channel properties .Recent report have shown that BDNF not only acts as a modulation of ion channels following TrkB-mediated activation of in-tracellular second messenger cascades and protein phosphorylation, but can also directly opens a Na⁺ channel. Thus, in addition its role as a potent neuromodulator，BDNF emerges as an excitatory transmitter.