天然药对CYP3A 的影响

天然药在我国及东南亚国家应用相当广泛, 在欧洲及美国, 天然药正日益受到重视。天然药成分虽复杂, 但其单体或有效成分与合成药一样, 大多数是通过细胞色素P450 酶(CYP450)代谢。CYP3A 是很重要的CYP450 酶系, 临床上一半以上药物由其代谢。目前很多体外、体内实验证明多种天然药及其成分广泛影响CYP3A, 从而在合并用药时, 导致药物间的相互作用。研究天然药对CYP3A 的调控不仅对安全合理用药有指导作用, 而且对于新药研发和揭示药物相互作用机制都有指导意义。

Effects of natural drugs on CYP3A

Natural drugs are widely used in China and Southeast Asia, and they are more and more popular in Europe and America.Though complicated their component are, their monomer and active ingredients are metabolized by CYP450s as synthetic drugs. CYP3A is one of the most important cytochrome P450, and more than half of drugs are metabolized by this enzyme.Now many in vitro and in vivo researches indicate that many natural drugs and the ingredients effect CYP3A widely, and lead to drug-drug interactions in combined use.So researching on the regulation of natural drugs will not only benefit medication safety, but also make sense to the development of new drugs and revealing the mechanism of drug-drug interactions.